Identificación de drogas que inhiben la funcionalidad de proteínas de unión al ARN en tripanosomátidos

Analía Gabriela Níttolo; María Clara Corso; Gabriela Vanesa Levy

doi:10.54789/rs.v3i1.32

Authors

Analía Gabriela Níttolo Universidad Nacional de La Matanza, Departamento de Ciencias de la Salud, San Justo, Argentina https://orcid.org/0000-0003-0389-273X
María Clara Corso Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (UNSAM) – Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín. https://orcid.org/0000-0002-9212-3483
Gabriela Vanesa Levy Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (UNSAM) – Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín. https://orcid.org/0000-0002-7638-3509

DOI:

https://doi.org/10.54789/rs.v3i1.32

Keywords:

Trypanosoma cruzi, Trypanosoma brucei, RNA-binding proteins, drug repositioning, daunorubicin, inhibitory concentration 50

Abstract

Trypanosoma cruzi and Trypanosoma brucei cause Chagas disease and African sleeping sickness, respectively. There are no vaccines and existing treatments are ineffective. The study of proteins relevant to the parasite represents promising therapeutic targets. Considering the RNA-binding protein TbRRM1 as a target, daunorubicin is proposed as a therapeutic compound, and its effectiveness in the survival of T. brucei is evaluated.

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